University of Pennsylvania researchers have developed a powerful new investigative tool to reveal how proteins work inside living cells. A technique that enables quick, precise and minimally ...

Creating analytical tools that support the advancement of knowledge can often come about through the integration of existing information and techniques, theoretical and practical, directed toward a ...

Proteins often function in pairs or groups, concealing their internal connection points and making it difficult for ...

Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...

Age-related changes in protein tagging and degradation may help explain how the brain declines over time and why diet can still influence these processes.

Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies. There is no known cure for Huntington's disease. A genetic ...

Rush hour never ceases at the nucleus’ border. Gene products begin their lives in the nucleus as strands of mRNA that ship out into the cytoplasm, where they serve as templates for protein synthesis.