A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment. The results ...

NUDT21 regulates fibroblast senescence and is significantly decreased in aged and fibrotic lungs, impacting IPF progression. Alternative polyadenylation (APA) and NUDT21 downregulation enhance STAT3 ...

Cell-based therapies can be developed in various ways, but companies look for methods that are faster and more efficient. At Houston, TX-based FibroBiologics scientists turn fibroblasts into ...

Cancer-associated fibroblasts (CAFs) get a bad rap. The protective, gel-like complex surrounding tumors have been thought to be a no-go for drugs and are known to enforce treatment resistance. But ...

A new research paper was published on the cover of Aging, titled "Human senescent fibroblasts trigger progressive lung fibrosis in mice." Cell senescence has recently emerged as a potentially relevant ...

Scientists have mapped underappreciated scaffolding cells in skin, known as fibroblasts. They show for the first time how fibroblasts go 'rogue' in many different diseases affecting multiple organs – ...

Cancer-associated fibroblasts (CAFs) are crucial in melanoma metastasis, influencing tumor microenvironments and patient outcomes, especially in immunotherapy contexts. Single-cell RNA sequencing ...

In a significant breakthrough in inflammatory arthritis research, a study published today (Feb. 23) in Nature Immunology has revealed that inflammation-associated fibroblasts—a type of cell in ...