The endoplasmic reticulum (ER) is central to protein synthesis, folding and modification, ensuring that the proteome of a cell remains functional and balanced. When the ER is overwhelmed by an ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

Protein synthesis, transport, and N-glycosylation are coupled at the mammalian endoplasmic reticulum by complex formation of a ribosome, the Sec61 protein-conducting channel, and ...

Janelia researchers have uncovered a novel way that two of the structures inside cells—the endoplasmic reticulum (ER) and lysosomes—coordinate the production of proteins, highlighting how interactions ...

Yeast, worms, and mice remodel their endoplasmic reticulum early in the aging process. The protective shift offers potential targets to extend healthy lifespan.

Researchers reveal how cells regenerate protein factories at endoplasmic reticulum. Researchers at LMU and Stanford University reveal how cells regenerate protein factories at endoplasmic reticulum.

Tsukuba, Japan—Researchers have been studying the transcription factor SREBP, a critical regulator of lipid biosynthesis. Precursor SREBP proteins, located in the endoplasmic reticulum (ER) of the ...

Endoplasmic reticulum (ER) stress and the unfolded protein response are often implicated in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), from simple steatosis ...

A cell contains many specialized subunits, called organelles, that carry out important tasks such as energy generation, protein synthesis, and calcium outflux. But what happens when something goes ...