The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut ...

Fewer than half of patients with FIC1 deficiency have their native liver at age 18. The number of PPTMs did not reliably predict the phenotype. However, sBA concentrations at baseline and after SBD ...

Bile acid metabolism disorders encompass a range of rare, yet clinically significant, genetic conditions that disrupt the normal synthesis and regulation of bile acids by the liver. These conditions, ...

Could bile acids--the fat-dissolving juices churned out by the liver and gallbladder--also play a role in immunity and inflammation? The answer appears to be yes, according to two separate Harvard ...

Could bile acids--the fat-dissolving juices churned out by the liver and gallbladder--also play a role in immunity and inflammation? The answer appears to be yes, according to two separate Harvard ...

The VDR is a member of the steroid/hormone nuclear receptor superfamily that includes 48 ligand-activated transcription factors. [3] These factors bind to conserved elements in the promoters of genes ...

(A) Female and male body weight change over the course of 16 weeks for FXR hep flox/flox and FXR hep-/- (B) Female and male liver-to-body weight ratios; (C) H&E stained liver sections (n=3–6); (D) ...

Bile is a digestive fluid produced by the liver to help in the digestion of fat and absorption of nutrients. However, if you experience reflux (the flow of stomach contents into the esophagus), you ...